What do cancer-specific T cells ‘see’?

Summary Complex cellular interactions between the immune system and cancer can impact tumour development, growth, progression. T cells play a key role in these interactions; however, challenge for is to recognize antigens whilst minimizing cross-reactivity with associated healthy tissue. Some cells, including those viral infections, have clear, tumour-specific that be targeted by cells. A high mutational burden lead increased numbers of neoantigens allow very specific responses generated but also escape variants develop. Other indications low are less easily distinguished from normal Recent studies suggested cancer-associated alterations cell biology changes post-translational modification (PTM) patterns may novel directly recognized The PTM-derived provide T-cell both central tolerance avoid necessity individualized therapies. PTM-specific CD4 shown therapy murine models highlight importance as well CD8 reversing immunosuppressive microenvironment. Understanding which cancer-specific way microenvironment shape vital future development